The conceit is that Sherlock Holmes is, as in reality, a fictional creation of Arthur Conan Doyle, but that the place where his office would be is maintained by the brilliant detective Shirley Holmes, who both solves crimes and maintains a museum for people who think Sherlock Holmes is real -- accompanied by a phonograph playing music from the Livanov series which had not long ended. She is accompanied, as might be expected, by a woman Watson, and must fight off the affections of both a Scotland Yard inspector an a parody Latin lover from Spain.
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