In 16th century Rome, Rampín, a friendly and shameless rogue, exploits his arts of deception. He lives with his aunt, Napolitana, a pimp dedicated to the same trades as his nephew. With the arrival of a beautiful Andalusian, Lozana, her fortune enters their house by making her the most beautiful courtesan in Rome. Lozana and Rampín reach an agreement: he will be at her service, taking her lovers home, and she will treat him like a king and give him the best, something that others will never have. But one fine day, Don Sancho, a handsome Spaniard, falls in love with her.
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